Futsal ve futbolcuların SLC6A4 geni 5-HTTLPR polimorfizmi ile saldırganlık düzeyleri arasındaki ilişkinin incelenmesi

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Thesis Type: Postgraduate

Institution Of The Thesis: Ondokuz Mayis University, Lisansüstü Eğitim Enstitüsü, Antrenörlük Eğitimi Anabilim Dalı, Turkey

Approval Date: 2021

Thesis Language: Turkish

Student: KÜBRA DURAN

Supervisor: Murat Eliöz

Open Archive Collection: AVESIS Open Access Collection

Abstract:

This study aims to investigate the distribution of the SLC6A4 gene 5-HTTLPR promotor zone's S and L alleles among female and male futsal and football players. It also determines the association between the SLC6A4 gene by identifying the aggression inventory and aggression levels. Voluntary and randomized 48 student-athletes in total, including 12 female football, 12 female futsal, 12 male football and 12 male futsal players, who have been actively engaging in sports for at least five years with an average age of 22-25, have participated in the study. The participants' quantitative data were collected by using the personal data sheets and the data collection tool "Aggression Scale Inventory". The OMU Karadeniz Advanced Technology Research and Application Center (KİTAM) Laboratory took complete blood sample for DNA isolation and genotyping. The study put forth that the athletes (n=48) had (%56,2) S allele in 5-HTTLPR polymorphism, (%100) A in rs2553 polymorphism and (%56,2) S in 5-HTTLPR/rs25531 polymorphism. When their genotype distribution was examined, the athletes were found to have (%50) L/S genotype in 5-HTTLPR polymorphism, (%100) A/A in rs25531 polymorphism and (%50) LA/S in 5-HTTLPR/rs25531 polymorphism. When the athletes (n=48) 5-HTTLPR polymorphisms, allele and genotypes were examined by their branches, no meaningful association with 5-HTTLPR and rs25531 allele, genotype, and serotonin functionality was found (p>0,05) however, a significant association was detected in the 5-HTTLPR/rs25531 allele distribution (p 0,05). No significant findings were identified in the comparison of the aggression sub-dimensions with their branches (p>0,05). As a result of the research; it was identified that the 5-HTTLPR and rs25531 polymorphisms of the SLC6A4 gene do not have a statistically significant association with aggression in futsal and football athletes. Specific gene research appears to be inadequate to identify a phenotype and therefore, multiple gene research is thought to be effective in phenotype definitions. It is also known that epigenetic factors may induce changes in phenotype as a result of their effects on methylation mechanisms. Therefore, it is suggested that sports genetics research should not be regarded as independent from epigenetic factors, and further reseaches should be done in this field. Keywords: Aggression; Epigenetics; Football; Futsal; Genetics; Slc6a4