A facile ionic liquid-accelerated, four-component cascade reaction protocol for the regioselective synthesis of biologically interesting ferrocene engrafted spiropyrrolidine hybrid heterocycles
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, cilt.32, sa.4, ss.2500-2504, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 4
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.jksus.2020.04.007
- Dergi Adı: JOURNAL OF KING SAUD UNIVERSITY SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, zbMATH, Directory of Open Access Journals
- Sayfa Sayıları: ss.2500-2504
- Anahtar Kelimeler: Multicomponent cycloaddition strategy, Ferrocene grafted spiroheterocyles, Indenoquinoxaline, Ionic liquids, 1,3-DIPOLAR CYCLOADDITION REACTIONS, ANTIMALARIAL ACTIVITY, IN-VITRO, MULTICOMPONENT
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Spiropyrrolidine engrafted ferrocene heterocycles were synthesized in excellent yields in a sustainable fashion employing an ionic liquid, 1-butyl-3-methylimidazoliumbromide accelerated one-pot multicomponent cycloaddition strategy. The in situ 1,3-dipole component derived from indenoquinoxalinone and L-phenylalanine that reacts with various substituted ferrocenyl chalcone in [bmim]Br affording spirocycloadduct. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.