CD117 expression in normal, neoplastic, inflammatory, and reactive lesions of the thyroid

Aydin O., Yıldız L., Kefeli M., Kandemir B.

PATHOLOGY RESEARCH AND PRACTICE, cilt.204, sa.6, ss.359-365, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 204 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.prp.2008.01.003
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.359-365
  • Anahtar Kelimeler: thyroid, c-kit, CD 117, immunohistochemical staining, C-KIT RECEPTOR, GASTROINTESTINAL STROMAL TUMORS, STEM-CELL FACTOR, SOFT-TISSUE SARCOMAS, OF-THE-LITERATURE, EWINGS-SARCOMA, IN-VITRO, CARCINOMA, MUTATIONS, LUNG
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The mutations of c-kit gene, which encodes a transmembrane receptor tyrosine kinase (CD117-KIT) or activation of CD 117, lead to the activation of signal transduction cascades regulating cell proliferation, apoptosis, chemotaxis, and adhesion.