Radioprotective effects of alpha 2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.396, sa.8, ss.1827-1836, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 396 Sayı: 8
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/s00210-023-02454-0
- Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1827-1836
- Anahtar Kelimeler: Beta-cell, Dexmedetomidine, Diabetes mellitus, Pancreas, X-ray irradiation, LONG-TERM SURVIVORS, DIABETES-MELLITUS, CHILDHOOD-CANCER, ABDOMINAL RADIATION, RISK, ENDOCRINE, RADIOTHERAPY, THERAPY
- Ondokuz Mayıs Üniversitesi Adresli: Hayır
Özet
Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet cell damage. Twenty-four rats were divided into three groups: group 1 (control group), group 2 (only X-ray irradiation group), and group 3 (X-ray irradiation + dexmedetomidine). We observed necrotic cells with vacuoles accompanying loss of cytoplasm in the islets of Langerhans, extensive edematous areas, and vascular congestions in group 2. In group 3, we observed a decrease in necrotic cells in the islets of Langerhans, and edematous areas and vascular congestion was also reduced. We determined a decrease in beta-cells, alpha-cells, and D-cells in the islets of Langerhans in group 2 compared to the control group. In group 3, beta-cells, alpha-cells, and D-cells were elevated compared to group 2. Ionizing radiation may induce DM. Dexmedetomidine appears to exert a radioprotective effect.