Effect of ranolazine on Tp-e interval, Tp-e/QTc, and P-wave dispersion in patients with stable coronary artery disease

Akçay M., Çoksevim M., Yenercag M.

JOURNAL OF ARRHYTHMIA, vol.37, no.4, pp.1015-1022, 2021 (ESCI, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1002/joa3.12549
  • Journal Name: JOURNAL OF ARRHYTHMIA
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.1015-1022
  • Keywords: coronary artery disease, index of cardiac electrophysiological balance (iCEB), P-wave dispersion, ranolazine, Tp-e interval, CHRONIC ANGINA, ATRIAL, RATIO, REPOLARIZATION, ELEVATION, EVENTS, INDEX, QT
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Introduction: Ranolazine is an antianginal drug and also exhibits antiarrhythmic effect by affecting action potential time, refractory period, and repolarization reserve. We evaluated the effect of ranolazine therapy on myocardial repolarization parameters (Tp-e, QT, QTc intervals, Tp-e/QT, and Tp-e/QTc ratios), index of cardiac electrophysiological balance (iCEB) (QT/QRS, QTc/QRS) and P-wave dispersion (PWD) in patients with stable coronary artery disease (CAD).