The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model
TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.5, pp.1602-1609, 2017 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 5
- Publication Date: 2017
- Doi Number: 10.3906/sag-1507-110
- Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.1602-1609
- Keywords: Subarachnoid hemorrhage, cerebral vasospasm, leptin, basilar artery, NITRIC-OXIDE, VASODILATION, OBESITY, HUMANS, GENE, RELATIVES, INSULIN, STROKE, MOUSE, CLUES
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood.