Is parturition-timing machinery related to the number of inhibitor CD94/NKG2A positive uterine natural killer cells?

Mazi E., Altunkaynak Z., Aydin I., Kocak I., Guven D., Türkmen A. P., ...Daha Fazla

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.294, sa.2, ss.261-265, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 294 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00404-015-3978-5
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-265
  • Anahtar Kelimeler: Parturition-timing machinery, uNK cells, CD94/NKG2A, Continuation of pregnancy, Preeclampsy, FETAL-GROWTH RESTRICTION, FETOMATERNAL INTERFACE, NORMAL-PREGNANCY, PRETERM BIRTH, PREECLAMPSIA, VARIANTS, MICE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Prematurity is the most common cause of infant mortality and morbidity. To prevent this, the timing of parturition and its mechanisms should be understood. It is likely that inhibitor CD94/NKG2A positive decidual natural killer cells (uNK) provide for the continuation of pregnancy. Here, we aimed to evaluate whether CD94/NKG2A positive uNK cells are highest in elective cesarian section (C/S) (suggesting ongoing gestation), moderate in normal full-term birth, and lowest in pre-eclamptic parturition.