The role of nitrergic system in lidocaine-induced convulsion in the mouse


Kurt M. S., Sirri Bilge S., Kukula O., Kesim Y., Çelik S. A.

Japanese Journal of Pharmacology, vol.85, no.1, pp.92-94, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1254/jjp.85.92
  • Journal Name: Japanese Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.92-94
  • Keywords: Convulsions, L-arginine, Lidocaine, N-nitro-L-arginine-methyl ester
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mice received physiological saline (0.9%), L-arginine (300 mg/kg, i.p.), L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg), respectively. Thirty minutes after these injections, all mice received lidocaine (50 mg/kg, i.p.). In the second experiment, four groups of mice received similar treatment in the first experiment, and 30 min after these injections, all mice received a higher dose of lidocaine (80 mg/kg). L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg) significantly decreased the incidence of lidocaine (50 mg/kg)-induced convulsions. In contrast, the L-arginine treatment increased the incidence of lidocaine (80 mg/kg, i.p.)-induced convulsions significantly. These results may suggest that NO is a proconvulsant mediator in lidocaine-induced convulsions.