Synthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde
TURKISH JOURNAL OF CHEMISTRY, cilt.44, sa.1, ss.237-256, 2020 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.3906/kim-1910-13
- Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.237-256
- Anahtar Kelimeler: Isatin, carbohydrazone, Schiff bases, DPPH, spectroscopic techniques, MANNICH-BASES, ANTIVIRAL ACTIVITY, ANTI-HIV, SCHIFF BASES, ANTIBACTERIAL, ANTIFUNGAL, CARBOHYDRAZONE, HYDRAZONES
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, H-1 NMR, and C-13 NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH center dot) free radical scavenging method. Compound 2 showed the best antioxidant activity.