Chemical constituents, in vitro antioxidant and antiproliferative activities of Perralderia coronopifolia Coss. subsp. eu-coronopifolia M. var. typica M. extract
Records of Natural Products, cilt.9, sa.3, ss.312-322, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 3
- Basım Tarihi: 2015
- Dergi Adı: Records of Natural Products
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.312-322
- Anahtar Kelimeler: Antioxidant activity, Antiproliferative activity, Asteraceae, Caffeoylquinic acids, Flavonoids, Perralderia coronopifolia, Terpenoids
- Ondokuz Mayıs Üniversitesi Adresli: Hayır
Özet
Phytochemical investigations of extracts from the aerial parts (leaves and flowers) of Perralderia coronopifolia Cosson resulted in the isolation of nine secondary metabolites corresponding to three flavonoids: rhamnazin(1), chrysosplenol D (3), and (2R, 3R) taxifolin (4), two monoterpene glycosides : myrtenol- β-D-glucopyranoside- 6'-O-acetate (2) and myrtenol β-D-glucopyranoside (7), a disaccharide: sucrose (9) and three di-O-caffeoylquinic acid derivatives : methyl 3, 5-di-O-caffeoyl quinate (5 ) and methyl 3,4-di-O-caffeoyl quinate (6 ) as a mixture and 1,5-di-O-caffeoylquinic acid (8). The structures were identified by spectroscopic methods such as 1H and 13C NMR, COSY, HSQC and HMBC experiments, HRESI-MS and comparison with literature data. Myrtenol-β-D-glucopyranoside-6'-O-acetate (2) was isolated in pure and native state for the first time. The other compounds are new for the genus Perralderia Cosson. The ethyl acetate extract showed a high antioxidant effect, especially DPPH radical scavenging activity with IC