Keratinocyte growth factor-2 and autologous serum potentiate the regenerative effect of mesenchymal stem cells in cornea damage in rats

Pinarli F. A., Okten G., Beden U., Fisgin T., Kefeli M., Kara N., ...Daha Fazla

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, cilt.7, sa.2, ss.211-219, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3980/j.issn.2222-3959.2014.02.05
  • Dergi Adı: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.211-219
  • Anahtar Kelimeler: corneal wound healing, mesenchymal stem cells, keratinocyte growth factor-2, autologous serum, amniotic membrane, TRANSPLANTATION, RECONSTRUCTION, MODEL, DIFFERENTIATION, EPITHELIUM, THERAPY, SURFACE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

AIM: To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells (MSCs) cultured with or without keratinocyte growth factor (KGF -2) and autologous serum (AS) on amniotic membrane (AM). Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency. Bone marrow -derived MSCs are potential sources for cell - based tissue engineering to repair or replace the corneal tissue, having the potential to differentiate to epithelial cells.