Development of an Electrochemical Sensor for Selective Determination of Dopamine Based on Molecularly Imprinted Poly(p-aminothiophenol) Polymeric Film

Ermis N., TINKILIÇ N.

ELECTROANALYSIS, vol.33, no.6, pp.1491-1501, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202060556
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1491-1501
  • Keywords: Electrochemical sensor, Gold electrode, Square wave voltammetry, Molecular imprinting, Dopamine, BIOMIMETIC SENSOR, GRAPHENE OXIDE, BIOSENSORS, ELECTRODE, DNA
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this study, a molecularly imprinted electrochemical sensor (MIP/DA) was investigated for selective and sensitive determination of dopamine (DA) by electrochemical polymerization of p-aminothiophenol in the presence of DA on gold electrode. According to electrochemical behaviour of the sensor, gained through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), MIP/DA sensor showed distinctive electron transfer characteristics in comparison to the non-imprinted (NIP/DA) sensor. Besides the MIP/DA sensor showed high selectivity for dopamine through its analyte specific cavities. The sensor had a broad working range of 5.0x10(-8)-2.0x10(-7) M with a limit of detection (LOD) of 1.8x10(-8) M and the developed sensor was successfully applied for determination of dopamine in pharmaceutical samples.