CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPC1 gene
plays a critical role in the atherosclerosis progression. This study aimed to examine whether 644 AG polymorphism
of NPC1 is associated with the risk of coronary artery disease in Turkish patients. In this case-control study, 200
persons were studied (100 patients and 100 controls). The 644 AG polymorphism of NPC1 gene is analyzed using
polymerase chain reaction and restriction fragment length polymorphism methods. There was a significant
relationship between the distribution of coronary artery disease and control group in terms of allele and genotype
frequency (p= 0.0002) (p=0.003), respectively. According to the researchers’ results, 644 AG polymorphism in
NPC1 gene can be one of the predisposition factor to coronary artery disease in Turkish population.