Mitosis and apoptosis in canine cutaneous histiocytoma and transmissible venereal tumour

Güvenç T., Haligur M., Orman M., HAZIROĞLU R. M.

Acta Veterinaria Hungarica, vol.50, no.3, pp.315-321, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1556/avet.50.2002.3.8
  • Journal Name: Acta Veterinaria Hungarica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.315-321
  • Keywords: Canine cutaneous histiocytoma, Canine transmissible venereal tumour, Differential diagnosis, Dog, Ki-67, Tunel
  • Ondokuz Mayıs University Affiliated: No

Abstract

Cell proliferation and apoptosis in canine cutaneous histiocytomas and transmissible venereal tumours were examined in twenty cases. The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. The number of Ki-67 immunoreactive cells was 11.65 (±1.1706) in canine cutaneous histiocytomas and 17 (±2.1751) in transmissible venereal tumours. The mean values of apoptotic cells for canine cutaneous histiocytomas and transmissible venereal tumours were 13.25 (±1.8758) and 8.52 (±1.1007), respectively. It was considered that mitotic activity and apoptotic indices were useful in differentiation of canine cutaneous histiocytomas and transmissible venereal tumours. The correlation values for canine cutaneous histiocytomas and transmissible venereal tumours were 0.359 (±0.330) and -0.232 (±0.344), respectively. No significant (P>0.05) correlation was found between mitosis and apoptosis in these two tumour types.