VNTR Variant of the eNOS Gene and its Relationship with Osteoporosis in Postmenopausal Turkish Women

NURSAL A. F., YİĞİT S., Tekcan A., ÖZSOY A. Z., ATEŞ H. Ö.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, vol.21, no.9, pp.1691-1695, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.2174/1871530320999200918120208
  • Journal Name: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1691-1695
  • Keywords: Osteoporosis, nitric oxide, endothelial nitric oxide synthase, VNTR, variant, PCR, OXIDE SYNTHASE GENE, BONE-MINERAL DENSITY, NITRIC-OXIDE, POLYMORPHISMS, ASSOCIATION, RISK, ESTROGEN, MICE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Osteoporosis (OP) is the most common type of systemic bone disease characterized by low bone mass and micro-structure deterioration of bone tissue, with a consequent increase in bone fragility and fracture risk. Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS) in endothelial cells, has considerable effects on bone cell function. The objective of this case-control study was to investigate the potential association between the eNOS gene Variable Number Tandem Repeat (VNTR) variant and susceptibility of OP, in Turkish postmenopausal female patients.