VNTR Variant of the eNOS Gene and its Relationship with Osteoporosis in Postmenopausal Turkish Women

NURSAL A. F., YİĞİT S., Tekcan A., ÖZSOY A. Z., ATEŞ H. Ö.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, cilt.21, sa.9, ss.1691-1695, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871530320999200918120208
  • Dergi Adı: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1691-1695
  • Anahtar Kelimeler: Osteoporosis, nitric oxide, endothelial nitric oxide synthase, VNTR, variant, PCR, OXIDE SYNTHASE GENE, BONE-MINERAL DENSITY, NITRIC-OXIDE, POLYMORPHISMS, ASSOCIATION, RISK, ESTROGEN, MICE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Osteoporosis (OP) is the most common type of systemic bone disease characterized by low bone mass and micro-structure deterioration of bone tissue, with a consequent increase in bone fragility and fracture risk. Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS) in endothelial cells, has considerable effects on bone cell function. The objective of this case-control study was to investigate the potential association between the eNOS gene Variable Number Tandem Repeat (VNTR) variant and susceptibility of OP, in Turkish postmenopausal female patients.