Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.32, no.3, pp.450-460, 2015 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 32 Issue: 3
- Publication Date: 2015
- Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.450-460
- Keywords: Cerebral vasospasm, subarachnoid hemorrhage, vascular morphometry, neurological outcome, zoledronic acid, NITRIC-OXIDE SYNTHASE, MESSENGER-RNA, UP-REGULATION, RHO-KINASE, BISPHOSPHONATE, SIMVASTATIN, INVOLVEMENT, INHIBITION, AGONIST, STATINS
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Background: Early brain injury and cerebral vasospasm are major factors determining outcome for patients who experience subarachnoid hemorrhage (SAH). This study was performed to investigate the potential therapeutic effects of zoledronic acid on cerebral vasospasm in an experimental SAH model.