Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats

Ulus A., Celik O., Arslanhan A., KAYA Ö. T., ÖZKAN M., YILMAZ GÖLER A. M., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.32, no.3, pp.450-460, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2015
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.450-460
  • Keywords: Cerebral vasospasm, subarachnoid hemorrhage, vascular morphometry, neurological outcome, zoledronic acid, NITRIC-OXIDE SYNTHASE, MESSENGER-RNA, UP-REGULATION, RHO-KINASE, BISPHOSPHONATE, SIMVASTATIN, INVOLVEMENT, INHIBITION, AGONIST, STATINS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Early brain injury and cerebral vasospasm are major factors determining outcome for patients who experience subarachnoid hemorrhage (SAH). This study was performed to investigate the potential therapeutic effects of zoledronic acid on cerebral vasospasm in an experimental SAH model.