Synthesis, spectroscopic, thermal Studies, antimicrobial activities and crystal structures of Co(II), Ni(II), Cu(II) and Zn(II)-orotate complexes with 2-methylimidazole

ERER H., YEŞİLEL O. Z., DARCAN C., Buyukgungor O.

POLYHEDRON, vol.28, no.14, pp.3087-3093, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 14
  • Publication Date: 2009
  • Doi Number: 10.1016/j.poly.2009.06.052
  • Journal Name: POLYHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3087-3093
  • Keywords: Orotate complexes, 2-Methylimidazole complexes, Antimicrobial activity, OROTIC-ACID, MOLECULAR-STRUCTURE, SPECTROTHERMAL PROPERTIES, VITAMIN-B13 COMPLEXES, COORDINATION MODE, NICKEL(II), OROTATE, CRYSTALLIZATION, COPPER(II), COBALT(II)
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The 2-methylimidazole complexes of Co(II), Ni(II), Cu(II) and Zn(II) orotates, mer-[Co(HOr)(H2O)(2)(2-meim)(2)] (1), mer-[Ni(HOr)(H2O)(2)(2-meim)(2)] (2), [Cu(HOr)(H2O)(2)(2-meim)] (3) and [Zn(HOr)(H2O)(2)(2-meim)] (4), were synthesized and characterized by elemental analysis, spectral (UV-Vis and Fr-IR) methods, thermal analysis (TG, DTG and DTA), magnetic susceptibility, antimicrobial activity studies and single crystal X-ray diffraction technique. The complexes 1 and 2 have distorted octahedral geometries with two monodentate 2-methylimidazole and one bidentate orotate and two aqua ligands. The complexes 3 and 4 have distorted square pyramidal and trigonal bipyramidal geometry, respectively, with one 2-methylimidazole, bidentate orotate and aqua ligands. The orotate coordinated to the metal(II) ions through deprotonated nitrogen atom of pyrimidine ring and oxygen atom of carboxylate group as a bidentate ligand. The antimicrobial activities of 1 and 4 were found to be more active gram (+) than gram (-) and 4 could be use for treatment Staphylococcus aureus. (C) 2009 Elsevier Ltd. All rights reserved.