Recent agricultural studies indicate that chlorpyrifos a commonly used organophosphate insecticide causes tissue damage. Studies conducted in recent years indicate that chlorpyrifos (cpf) triggered this damage by forming free radicals. Curcumin (cur) is a free radical sweeping antioxidant derived from turmeric. In our study, we aimed to investigate, histopathologically, the antioxidant and possible protective effects of curcumin against chromosome damage caused by chlorpyrifos. 40 adult male rats were divided into two groups, 15 day group and 30 day group. Each group was divided into 4 subgroups: control, chlorpyrifos, curcumin and chlorpyrifos+curcumin. chlorpyrifos and curcumin were administered orally to the animals. Chlorpyrifos was given orally via gavage daily at a dose of 5 mg/kg and 100 mg/kg curcumin was administered orally every day. In the chlorpyrifos+curcumin groups, curcumin was administrated before chlorpyrifos. At the end of 15 and 30 days, the rats were sacrified post 2.5 hours colchicine administration. Marrows were taken from the femoral bone. Smear slides of chromosomes were stained with Giemsa. The control and curcumin groups had normal chromosomes. Serious chromosomal disorders in chlorpyrifos group depending on the time of exposure were detected. As a result of this study, it was concluded that curcumin reduced chlorpyrifos induced chromosomal aberrations.