Effects of leflunomide on inflamation and fibrosis in bleomycine induced pulmonary fibrosis in wistar albino rats

Kayhan S., Guzel A., Duran L., Tütüncü Ş., Guzel A., Gunaydin M., ...Daha Fazla

JOURNAL OF THORACIC DISEASE, cilt.5, sa.5, ss.641-649, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3978/j.issn.2072-1439.2013.09.20
  • Dergi Adı: JOURNAL OF THORACIC DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.641-649
  • Anahtar Kelimeler: Animal model, anti-inflammatory, Il-6, lungs, superoxide dismutase (SOD), RHEUMATOID-ARTHRITIS, PATHOGENESIS, INFLAMMATION, MECHANISM, THERAPY, MODELS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purposes: Pulmonary fibrosis is a rare and progressive lung disease with a high mortality rate. The treatment regimens still fail to recover the disease. Leflunomide (LEF) is an immunomodulatory agent with antiproliferative activity that is used for the treatment of rheumatoid arthritis. The purpose of the study is to investigate the potential therapeutic efficacy of LEF in bleomycin (BLM) induced pulmonary fibrosis.