Can empirical hypertonic saline or sodium bicarbonate treatment prevent the development of cardiotoxicity during serious amitriptyline poisoning? Experimental research

Paksu, Muhammet; Zengin, Halit; Ilkaya, Fatih; Paksu, Sule; Guzel, Hasan; Ucar, Durmus; Uzun, Adem; Alacam, Hasan; Duran, Latif; Murat, Naci; Guzel, Ahmet

doi:10.5830/cvja-2015-014

Can empirical hypertonic saline or sodium bicarbonate treatment prevent the development of cardiotoxicity during serious amitriptyline poisoning? Experimental research

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Paksu M. S., Zengin H., Ilkaya F., Paksu S., Guzel H., Ucar D., ...More

CARDIOVASCULAR JOURNAL OF AFRICA, vol.26, no.3, pp.134-139, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 26 Issue: 3
Publication Date: 2015
Doi Number: 10.5830/cvja-2015-014
Journal Name: CARDIOVASCULAR JOURNAL OF AFRICA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.134-139
Keywords: amitriptyline, poisoning, cardiotoxicity, sodium bicarbonate, hypertonic saline, TRICYCLIC ANTIDEPRESSANT OVERDOSE, INDUCED CARDIOVASCULAR TOXICITY, CHARCOAL HEMOPERFUSION, INTOXICATION, CHILDREN, RATS, HYPERVENTILATION, HYPONATREMIA, HYPOTENSION, EMERGENCY
Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: The aim of this experimental study was to investigate whether hypertonic saline or sodium bicarbonate administration prevented the development of cardiotoxicity in rats that received toxic doses of amitriptyline.