Antiinflammatory and antioxidant effects of gemcitabine in collagen-induced arthritis model

Dagli A. F., KARATAŞ A., ORHAN C., TUZCU M., Özgen M., ŞAHİN K., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.3, pp.1037-1044, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1606-80
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1037-1044
  • Keywords: Rheumatoid arthritis, collagen-induced arthritis, gemcitabine, western blotting, RHEUMATOID-ARTHRITIS, DISEASE, NRF2, INFLAMMATION, CELLS, INTERLEUKIN-17, PATHOGENESIS, IMPROVEMENT, METABOLISM, CANCER
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background/aim: Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA).