Phytochemical studies and antibacterial activity of the aerial parts of physospermum verticillatum

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Boulacel I., Djarri L., Azzouzi S., Medjroubi K., Demirtas İ., Laouer H., ...More

Bangladesh Journal of Pharmacology, vol.12, no.2, pp.107-112, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.3329/bjp.v12i2.29668
  • Journal Name: Bangladesh Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.107-112
  • Keywords: Antibacterial, Physospermum verticillatum
  • Ondokuz Mayıs University Affiliated: No


In this study, we focused on the isolation and identification of the main compounds, triterpene, sterol, phenolic and fatty acid from the aerial parts of Physospermum verticillatum, which has not been previously reported. Dichloro-methane, ethyl acetate and n-butanol extracts led to the isolation of ß-amyrin (1), 3,11-dihydroxy-12-oleanene (2), pentadecanoic acid (3), spina-sterol (4), spinasterol-3-O-ß-D-glucopyranoside (5) and saikochromic acid (6). These compounds were determined by means of the combined systems with high resolution tandem mass spectrometry (HPLC-TOF/MS), 1D NMR (1 H NMR,13C NMR) and 2D NMR(COSY, HSQC and HMBC). Further, the extracts demonstrated significant antibacterial activity.