Synthesis and X-ray crystal structures of two different zinc (II) complexes of N,N'-cyclohexane-1,2-diylidene-bis(4-fluorobenzoylhydrazide) based on zinc salt effect

OmarAli A. B., Al-Karawi A. J. M., DEGE N., Kansiz S., Ithawi H. A. D.

JOURNAL OF MOLECULAR STRUCTURE, vol.1217, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1217
  • Publication Date: 2020
  • Doi Number: 10.1016/j.molstruc.2020.128387
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Keywords: Distorted dodecahedral Zn-complex, Tetrahedral, Eight-coordinate, Bis(aroylhydrazone), Biological activity, Zinc salt effect, TRANSITION-METAL-COMPLEXES, ANTIOXIDANT ACTIVITY, HYDRAZONE, LIGAND, NI(II), CU(II), COPPER(II), SOLVENTS, BINDING, CO(II)
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Reaction of zinc chloride or zinc nitrate hexahydrate with N,N '-cyclohexane-1,2-diylidene-bis(4-fluorobenzoylhydrazide) (L) in acetonitrile and under ambient conditions, produced two different zinc(II) complexes 1 and 2 respectively, with different coordination modes and geometrical shapes. A neutral four-coordinate complex with typical tetrahedral geometry was obtained for 1, in which, the zinc atom is sited outside the bis aroyl hydrazone core. While, a cationic eight-coordinate complex with distorted dodecahedral geometry was confirmed for 2, in which, the zinc atom is surrounded by four oxygen and four nitrogen donors from two N,N'-cyclohexane-1,2-diylidene-bis(4-fluorobenzoylhydrazide) molecules. The prepared compounds were identified and their chemical structures determined using various techniques: Nuclear magnetic resonance (NMR), Infrared (IR) and Ultravioletvisible (UVVis) spectroscopy, in addition to single-crystal X-ray crystallography, X-ray powder diffraction (XRD), elemental analysis, atomic absorption and molar conductivity measurements. Furthermore, the in vitro biological activity of L, 1 and 2 was studied against some selected bacterial strains: Bacillus subtilis and Staphylococcus aureus as gram positive bacteria, and Escherichia coli and Salmonella typhimurium as gram negative bacteria. The study revealed that the prepared compound have shown a differentiated biological activity against these bacteria depending on their structural features and lipophilic nature. (C) 2020 Elsevier B.V. All rights reserved.