Analysis of YKL-40 Acute-Phase Protein and Interleukin-6 Levels in Periodontal Disease

Keles Z. P., Keles G. C., Avcı B., Özkan Çetinkaya B., EMİNGİL G.

JOURNAL OF PERIODONTOLOGY, vol.85, no.9, pp.1240-1246, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.1902/jop.2014.130631
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1240-1246
  • Keywords: Acute-phase proteins, CHI3L1 protein, human, gingival crevicular fluid, interleukin-6, periodontal diseases, serum, YKL 40 protein, human, GINGIVAL CREVICULAR FLUID, C-REACTIVE PROTEIN, SERUM YKL-40, ENDOTHELIAL DYSFUNCTION, INFLAMMATORY BIOMARKER, RHEUMATOID-ARTHRITIS, MARKER, PLASMA, PARAMETERS, CYTOKINES
  • Ondokuz Mayıs University Affiliated: Yes


Background: YKL-40, a new acute-phase protein, is shown to be elevated in inflammatory diseases, such as rheumatoid arthritis, type 2 diabetes mellitus, and coronary artery diseases. However, there is no data indicating a relationship between YKL-40 and periodontal disease. Interleukin-6 (IL-6) is the major regulator of acute-phase protein synthesis and one of the most studied inflammatory markers in periodontal disease. The purpose of the present study is to evaluate YKL-40 and IL-6 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals.