Genotoxicity assessment using comet assay in Behcet's disease patients

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Bilgici B., Bedir A., Senturk N., Alvur M., Aydin F., Turanli A.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, vol.578, no.1-2, pp.170-174, 2005 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 578 Issue: 1-2
• Publication Date: 2005
• Doi Number: 10.1016/j.mrfmmm.2005.05.011
• Journal Name: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.170-174
• Keywords: genotoxicity, Behcet's disease, comet assay, single cell gel electrophoresis, DNA-DAMAGE, MALIGNANCY, CANCER, CELLS
• Ondokuz Mayıs University Affiliated: No

Abstract

Behcet's disease (BD) was originally described by Turkish dermatologist, Hulusi Behcet in 1937. BD is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. All these common manifestations are self-limiting except for ocular attacks. The aims of this study were to assess whether BD patients have more genotoxicity than healthy controls and whether colchicine (COL) treated BD patients are different from those not using COL in terms of genotoxicity.