Iodine deficiency: A probable cause of neural tube defect

Sarici D., KARAYOL AKIN A., Kurtoglu S., Akin L., Tucer B., Yikilmaz A., ...More

Child's Nervous System, vol.29, no.6, pp.1027-1030, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00381-013-2038-3
  • Journal Name: Child's Nervous System
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1027-1030
  • Keywords: Iodine deficiency, Myelomeningocele, Neural tube defect, Neuroenteric cyst, Newborn
  • Ondokuz Mayıs University Affiliated: No


Introduction: Iodine deficiency is the most devastating event in developing brain in the fetus and neonate. Iodine is absolutely necessary on the myelination, neuronal differentiation, and formation of neural processes, synaptogenesis, and neuronal migration by thyroidal hormones throughout pregnancy and shortly after birth. Neural tube defects (NTD) form after third and fourth gestational weeks and their etiologies are multifactorial. Case report: We herein present a male newborn with iodine deficiency and thoracic neuroenteric cyst bound to a myelomeningocele via a pedinculi. We hypothesize that iodine deficiency may be a cause of NTD, and iodine supplementation in preconception and pregnancy may prevent NTD. © 2013 Springer-Verlag Berlin Heidelberg.