The expression of vascular endothelial growth factor in a rat model at destruction and healing stages of periodontal disease

Cetinkaya B. O., Keles G. C., Ayas B., Sakallioglu E. E., Acikgoz G.

JOURNAL OF PERIODONTOLOGY, vol.78, no.6, pp.1129-1135, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1902/jop.2007.060397
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1129-1135
  • Keywords: angiogenesis, periodontal disease, vascular endothelial growth factor, wound healing, INDUCED GINGIVAL OVERGROWTH, CYCLOSPORINE-A, PERMEABILITY FACTOR, BONE-FORMATION, ANGIOGENESIS, CELLS, PROGRESSION, INHIBITION, TISSUES, ROLES
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The major role of vascular endothelial growth factor (VEGF), an angiogenic mediator, in promoting the progression or the healing of periodontal disease is still unclear. The aim of this study was to evaluate the VEGF expression in the destruction and healing stages of periodontal disease and to investigate the association between VEGF expression and vascularization with regard to the number and diameters of blood vessels.