Urinary leucine aminopeptidase is a more sensitive indicator of early renal damage in non-lnsulin-dependent diabetics than microalbuminuria

Bedir A., Özener İ. Ç., Emerk K.

Nephron, vol.74, no.1, pp.110-113, 1996 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 1
  • Publication Date: 1996
  • Doi Number: 10.1159/000189288
  • Journal Name: Nephron
  • Journal Indexes: Scopus
  • Page Numbers: pp.110-113
  • Keywords: Albuminuria, Diabetes mellitus, Diabetic nephropathies, Leucine aminopeptidase, Non-insulin-dependent
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

We measured urinary activity of leucine aminopeptidase (EC 3.4.11.2) and creatinine concentrations (Cr, in mmol) in samples of second morning urine from 25 healthy subjects and 59 non-insulin-dependent diabetic (NIDD) subjects. If NIDD subjects are grouped according to their Alb/Cr ratio into nor-moalbuminuria (group A, Alb/Cr < 2.8 mg/mmol), microalbuminuria (group B, Alb/Cr 2.8-26.8 mg/mmol), and macroalbuminuria (group C, Alb/Cr > 26.8 mg/mmol), LAP/Cr ratios in all three groups exceeded those for healthy age-matched controls. Moreover, this ratio was higher in group B than in group A. The value for LAP/Cr was clearly abnormal (i.e. exceeded the upper limit of normal, log normal + 2 SD, found in healthy subjects) in 44% of group A. In the first 10-year period of NIDD, prevalance of abnormal LAP/Cr ratio was 61.3%, whereas that of microalbuminuria was 35.5%. We have also found a LAP/Cr ratio abnormality of 91% in group B. Evidently, LAP/Cr may be increased early in NIDD subjects and be a more sensitive predictor of incipient nephropathy than microalbuminuria. © 1996 S. Karger AG, Basel.