The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-alpha in the gingival crevicular fluid of obese patients following periodontal therapy

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BALLI U., Dogan S. B., DEDE F. Ö., Sertoglu E., Keles G. C.

JOURNAL OF ORAL SCIENCE, vol.58, no.4, pp.465-473, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.2334/josnusd.16-0212
  • Journal Name: JOURNAL OF ORAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.465-473
  • Keywords: visceral adipose-specific serpin, human omentin-1 protein, human, tumor necrosis factor-alpha, periodontal disease, obesity, METABOLIC SYNDROME, CIRCULATING LEVELS, GENE-EXPRESSION, VASPIN LEVELS, SERUM-LEVELS, KAPPA-B, ASSOCIATION, ADIPOKINES, DISEASE, INFLAMMATION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-a. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-alpha (P < 0.008), which declined following treatment (P< 0.025), and lower omentin levels (P <0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome.