The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents

Gunaydin M., Guzel A., Guzel A., Alacam H., Salis O., Murat N., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.47, no.9, pp.1669-1676, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jpedsurg.2012.01.076
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1669-1676
  • Keywords: Acute lung injury, Inflammation, Gastrointestinal decontamination, Activated charcoal, Polyethylene glycol, Curcumin, Rat, RESPIRATORY-DISTRESS-SYNDROME, GLYCOL-ELECTROLYTE SOLUTION, SURFACTANT PROTEIN-A, ACTIVATED-CHARCOAL, CONTROLLED-TRIAL, PULMONARY-EDEMA, NITRIC-OXIDE, INFLAMMATION, FAILURE, PERMEABILITY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Aspiration is one of the most feared complications of gastrointestinal decontamination procedures with nonabsorbed polyethylene glycol (PEG) solution and activated charcoal (AC). We aimed to investigate the protective effects of curcumin (CUR) on lung injury in rats induced by aspiration of these agents.