Research Information System
TUBERKULOZ VE TORAKS, vol.71, no.3, pp.203-214, 2023 (ESCI)
Introduction: The aim of this study was to assess the potential of subcutane-ous adipose tissue volume, mediastinal adipose tissue volume, lung density, and lung volume (as measured on high-resolution computed tomography) to predict disease progression in patients with idiopathic pulmonary fibrosis (IPF). Additionally, the study aimed to evaluate the changes in these semi-quantitative measures over time.Materials and Methods: The HRCT images of 57 patients diagnosed with IPF were retrospectively screened. Subcutaneous adipose tissue volume, medias-tinal adipose tissue volume, and mean lung density and volume were meas-ured at the time of diagnosis and at the 12th month. The ability of these parameters to predict progression was evaluated using the univariate and multivariate Cox regression analyses.Results: Low mediastinal adipose tissue volume at diagnosis had a 0.991-fold effect [odds ratio (OR)= 0.991, 95% confidence interval (CI)= 0.984-0.997, p< 0.0011 on progression. Low mediastinal adipose tissue volume at diagnosis had a 0.993-fold effect [odds ratio (OR)= 0.993, 95% confidence interval (CI)= 0.975-1.011, p< 0.0011 and progression development at the 12th month had a 6.5-fold effect [odds ratio (OR)= 6.516, 95% confidence interval (CI)= 1.594-26.639, p< 0.0091 on mortality.Conclusion: This study indicate that the prognosis was better in those with a large mediastinal adipose tissue volume among the patients with IPF.