A case of imipramine-associated immune thrombocytopenia


Aksoy A., ERDURAN E., Gedik Y.

Turkish Journal of Pediatrics, vol.51, no.3, pp.275-278, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2009
  • Journal Name: Turkish Journal of Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.275-278
  • Keywords: Imipramine, Immune thrombocytopenia
  • Ondokuz Mayıs University Affiliated: No

Abstract

Drug-induced immune thrombocytopenia (DITP), excluding heparin-induced thrombocytopenia, is relatively uncommon. It is characterized by drug-dependent antibodies that bind to the platelets and cause their destruction when the responsible drug is ingested or injected. Imipramine is a tricyclic antidepressant drug that is one of those used widely for primary enuresis nocturna, attention deficit hyperactivity disorder, depression, and anxiety disorder in children and adolescents. Imipramine rarely causes hematological abnormalities. A five-year-old boy with imipramine-associated antiglobulin-positive immune thrombocytopenia is reported herein, and we also discuss the possible pathogenesis of drug-associated thrombocytopenia.