Is melatonin, leptin or their combination more effective on oxidative stress and folliculogenesis in the obese rats?

Kirikci G., ALTUNKAYNAK B. Z., Kaplan S.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.40, no.1, pp.116-127, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1080/01443615.2019.1657816
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.116-127
  • Keywords: Body mass index, weight loss, ovarian morphology, leptin, melatonin, stereology, HIGH-FAT, PROTECTS, CELLS, EXPRESSION, INHIBITOR, APOPTOSIS, NUMBER, HEALTH, NERVE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this study, we evaluated the effects of melatonin (Mel), leptin (Lep) or melatonin and leptin treatment on ovaries in control and obese rats. The animals were divided into control (NC), melatonin (NM), leptin (NL), melatonin?leptin (NML), obese (OC), obese?melatonin (OM), obese?leptin (OL), obese?melatonin?leptin (OML) groups. Body weights, peri-ovarian fat pads, volumetric parameters and numerical values of follicles were estimated. Also, the LH receptor (LHr) immune-positivity, catalase (CAT) and the myeloperoxidase (MPO) levels were determined. The body weight and peri-ovarian fat pads were significantly decreased following Mel (p?