Copeptin: a diagnostic factor for critical patients

Yilman M., Erenler A. K., Baydin A.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.19, sa.16, ss.3030-3036, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 16
  • Basım Tarihi: 2015
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3030-3036
  • Anahtar Kelimeler: Copeptin, Critical care, Emergency Department, ACUTE MYOCARDIAL-INFARCTION, PULMONARY ARTERIAL-HYPERTENSION, STABLE PEPTIDE, VASOPRESSIN PRECURSOR, NATRIURETIC PEPTIDE, HEART-FAILURE, SUBARACHNOID HEMORRHAGE, ARGININE-VASOPRESSIN, RISK STRATIFICATION, ACUTE EXACERBATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Copeptin is important in determining the prognosis of the disease, assigning mortality, setting treatment modalities and increasing the patients' chances for survival in life threatening conditions. Any stress factor activating the hypothalamic-pituitary-adrenal (HPA) axis causes an increase in arginine vasopressin (AVP) plasma concentrations also known as antidiuretic hormone (ADH). Copeptin is derived from preprovasopressin along with neurophysin II and AVP. Copeptin is released in an equimolar ratio to AVP. Various studies have shown copeptin to be an independent indicator in determining the prognosis of the disease and assigning mortality. The purpose of this review was to analyze the advantages of copeptin in patients with life threatening illnesses by reviewing medical data bases.