New 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities

MUĞLU H., Yakan H., Shouaib H. A.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1203, 2020 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1203
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.molstruc.2019.127470
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Anahtar Kelimeler: Thiophene-2-carboxylic acid, 1,3,4-Thiadiazoles, N-arylthiosemicarbazides, Antimicrobial activity, Spectroscopic methods, DERIVATIVES SYNTHESIS, ANTICONVULSANT, 1,2,4-TRIAZOLE, ANTIBACTERIAL, 1,3,4-OXADIAZOLES, MOIETY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Novel 1,3,4-thiadiazole derivatives were prepared by cyclization reaction of thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl3. The antibacterial activities of the synthesized compounds were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans), and the fungus Candida albicans using the disk diffusion method. Selected 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, C. albicans, S. typhimurium, E. aerogenes, and S. kentucky. Therefore, 1,3,4-thiadiazole derivatives can be considered as bioactive agents for pharmacological and medicinal applications. The synthesized compounds were characterized by using IR, H-1 NMR, and C-13 NMR spectroscopies and elemental analysis. (C) 2019 Elsevier B.V. All rights reserved.