Synthesis, Anti-Bacterial and Anti-Oxidant Activity of Azo-Oxazolone and Their Ring Opening Azo-Benzamide Derivatives

Ayoob M. M., Hussein A. J., Samad M. K., DEGE N., Hawaiz F. E., Mohamed S. K., ...Daha Fazla

CURRENT ORGANIC SYNTHESIS, cilt.18, sa.5, ss.493-505, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1570179417666201218163435
  • Dergi Adı: CURRENT ORGANIC SYNTHESIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.493-505
  • Anahtar Kelimeler: Azo-oxazolone, azo-benzamide, antimicrobial, antioxidant, ring-opening reaction, MS spectrometry, BIOLOGICAL EVALUATION, ANTIMICROBIAL EVALUATION, IMIDAZOLONE, DESIGN, POWER
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

This article describes the controlled synthesis and characterization of azo oxazolone scaffold compounds containing multifunctional groups such as carbonyl group, imine and carbon-carbon double bond. The reaction of the azo-oxazolone with aromatic amines led to the ring-opening of the azo-oxazolone into the corresponding azo-benzamide derivatives in a short time (average 10 min), resulting in high yield (>90%). All newly synthesized compounds were characterized by the common spectral analysis such as UV, IR, H-1-NMR, C-13-NMR, Elemental analysis and MS spectrometry.