Synthesis, Anti-Bacterial and Anti-Oxidant Activity of Azo-Oxazolone and Their Ring Opening Azo-Benzamide Derivatives

Ayoob M. M., Hussein A. J., Samad M. K., DEGE N., Hawaiz F. E., Mohamed S. K., ...More

CURRENT ORGANIC SYNTHESIS, vol.18, no.5, pp.493-505, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.2174/1570179417666201218163435
  • Journal Name: CURRENT ORGANIC SYNTHESIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.493-505
  • Keywords: Azo-oxazolone, azo-benzamide, antimicrobial, antioxidant, ring-opening reaction, MS spectrometry, BIOLOGICAL EVALUATION, ANTIMICROBIAL EVALUATION, IMIDAZOLONE, DESIGN, POWER
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

This article describes the controlled synthesis and characterization of azo oxazolone scaffold compounds containing multifunctional groups such as carbonyl group, imine and carbon-carbon double bond. The reaction of the azo-oxazolone with aromatic amines led to the ring-opening of the azo-oxazolone into the corresponding azo-benzamide derivatives in a short time (average 10 min), resulting in high yield (>90%). All newly synthesized compounds were characterized by the common spectral analysis such as UV, IR, H-1-NMR, C-13-NMR, Elemental analysis and MS spectrometry.