Antiproliferative effects of the methanolic extracts of Sideritis libanotica Labill. subsp. linearis

Demirtas İ., Sahin A., Ayhan B., Tekin S., Telci I.

Records of Natural Products, vol.3, no.2, pp.104-109, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 2
  • Publication Date: 2009
  • Journal Name: Records of Natural Products
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.104-109
  • Keywords: Antiproliferation, Plant extracts, Sideritis libanotica, Vero cells
  • Ondokuz Mayıs University Affiliated: No

Abstract

Methanol extract from aerial parts of Sideritis libanotica Labill. subsp. linearis (Bentham) Borm. were investigated for its in vitro antiproliferative activities against Vero, HeLa and C6 cells. The tests were carried out as dose-dependent assay starting from 25 μg/mL to 250 μg/mL. The extract found to be active against African green monkey kidney (Vero), human uterus carcinoma (HeLa) and Rat Brain tumor cells (C6) cancer cell lines with IC50 values. The methanol extract of S. libanotica showed the highest activity against the Vero, HeLa and C6 cell lines at 250 μg/mL as dose-dependent assay starting from 25 μg/mL.