A facile ionic liquid-accelerated, four-component cascade reaction protocol for the regioselective synthesis of biologically interesting ferrocene engrafted spiropyrrolidine hybrid heterocycles
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, vol.32, no.4, pp.2500-2504, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 32 Issue: 4
- Publication Date: 2020
- Doi Number: 10.1016/j.jksus.2020.04.007
- Journal Name: JOURNAL OF KING SAUD UNIVERSITY SCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, zbMATH, Directory of Open Access Journals
- Page Numbers: pp.2500-2504
- Keywords: Multicomponent cycloaddition strategy, Ferrocene grafted spiroheterocyles, Indenoquinoxaline, Ionic liquids, 1,3-DIPOLAR CYCLOADDITION REACTIONS, ANTIMALARIAL ACTIVITY, IN-VITRO, MULTICOMPONENT
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Spiropyrrolidine engrafted ferrocene heterocycles were synthesized in excellent yields in a sustainable fashion employing an ionic liquid, 1-butyl-3-methylimidazoliumbromide accelerated one-pot multicomponent cycloaddition strategy. The in situ 1,3-dipole component derived from indenoquinoxalinone and L-phenylalanine that reacts with various substituted ferrocenyl chalcone in [bmim]Br affording spirocycloadduct. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.