A facile ionic liquid-accelerated, four-component cascade reaction protocol for the regioselective synthesis of biologically interesting ferrocene engrafted spiropyrrolidine hybrid heterocycles

Arumugam N., Almansour A., Kumar R. S., DEGE N.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE, vol.32, no.4, pp.2500-2504, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jksus.2020.04.007
  • Journal Name: JOURNAL OF KING SAUD UNIVERSITY SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, zbMATH, Directory of Open Access Journals
  • Page Numbers: pp.2500-2504
  • Keywords: Multicomponent cycloaddition strategy, Ferrocene grafted spiroheterocyles, Indenoquinoxaline, Ionic liquids, 1,3-DIPOLAR CYCLOADDITION REACTIONS, ANTIMALARIAL ACTIVITY, IN-VITRO, MULTICOMPONENT
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Spiropyrrolidine engrafted ferrocene heterocycles were synthesized in excellent yields in a sustainable fashion employing an ionic liquid, 1-butyl-3-methylimidazoliumbromide accelerated one-pot multicomponent cycloaddition strategy. The in situ 1,3-dipole component derived from indenoquinoxalinone and L-phenylalanine that reacts with various substituted ferrocenyl chalcone in [bmim]Br affording spirocycloadduct. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.