A facile ionic liquid-accelerated, four-component cascade reaction protocol for the regioselective synthesis of biologically interesting ferrocene engrafted spiropyrrolidine hybrid heterocycles

Arumugam N., Almansour A., Kumar R. S., DEGE N.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE, cilt.32, sa.4, ss.2500-2504, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jksus.2020.04.007
  • Dergi Adı: JOURNAL OF KING SAUD UNIVERSITY SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, zbMATH, Directory of Open Access Journals
  • Sayfa Sayıları: ss.2500-2504
  • Anahtar Kelimeler: Multicomponent cycloaddition strategy, Ferrocene grafted spiroheterocyles, Indenoquinoxaline, Ionic liquids, 1,3-DIPOLAR CYCLOADDITION REACTIONS, ANTIMALARIAL ACTIVITY, IN-VITRO, MULTICOMPONENT
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Spiropyrrolidine engrafted ferrocene heterocycles were synthesized in excellent yields in a sustainable fashion employing an ionic liquid, 1-butyl-3-methylimidazoliumbromide accelerated one-pot multicomponent cycloaddition strategy. The in situ 1,3-dipole component derived from indenoquinoxalinone and L-phenylalanine that reacts with various substituted ferrocenyl chalcone in [bmim]Br affording spirocycloadduct. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.