Bone mineral density in children with cerebral palsy

Tasdemir H. A., Buyukavci M., Akcay F., Polat P., Yildiran A., Karakelleoglu C.

Pediatrics International, vol.43, no.2, pp.157-160, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1046/j.1442-200x.2001.01352.x
  • Journal Name: Pediatrics International
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.157-160
  • Keywords: Bone mineral density, Cerebral palsy
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP). Methods: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D3 (25OHD3) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean (± SD) 4.1 ± 2.9 years). These values were compared with data obtained from a control group. Results: Adjusted mean BMD values were lower in the patient group than in controls (P < 0.05). However, there was no difference between BMD values of ambulant and non-ambulant patients. The Ca and P levels of the patient group were significantly higher than those of controls (P < 0.05). Conclusions: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.