A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120

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Newman J., Karakaya H., Scanlan D. J., Mann N. H.

FEMS Microbiology Letters, vol.133, no.1-2, pp.187-193, 1995 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 1-2
  • Publication Date: 1995
  • Doi Number: 10.1016/0378-1097(95)00369-g
  • Journal Name: FEMS Microbiology Letters
  • Journal Indexes: Scopus
  • Page Numbers: pp.187-193
  • Keywords: Anabaena, Fructose-1,6-bisphosphatase, Glucose-6-phosphate dehydrogenase, Synechococcus, zwf
  • Ondokuz Mayıs University Affiliated: Yes


The region of the genome encoding the glucose-6-phosphate dehydrogenase gene zwf was analysed in a unicellular cyanobacterium, Synechococcus sp. PCC 7942, and a filamentous, heterocystous cyanobacterium, Anabaena sp. PCC 7120. Comparison of cyanobacterial zwf sequences revealed the presence of two absolutely conserved cysteine residues which may be implicated in the light/dark control of enzyme activity. The presence in both strains of a gene fbp, encoding fructose-1,6-bisphosphatase, upstream from zwf strongly suggests that the oxidative pentose phosphate pathway in these organisms may function to completely oxidize glucose 6-phosphate to CO2. The amino acid sequence of fructose-1,6-bisphosphatase does not support the idea of its light activation by a thiol/disulfide exchange mechanism. In the case of Anabaena sp. PCC 7120, the tal gene, encoding transaldolase, lies between zwf and fbp. © 1995.