Effects of Risedronate on Alveolar Bone Loss and Angiogenesis: A Stereologic Study in Rats

Özkan Çetinkaya B., Keles G. C., Ayas B., Gurgor P.

JOURNAL OF PERIODONTOLOGY, vol.79, no.10, pp.1950-1961, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1902/jop.2008.080041
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1950-1961
  • Keywords: Angiogenesis, animal studies, bisphosphonates, osteonecrosis, periodontitis, risedronate, BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS, EXPERIMENTAL PERIODONTITIS, IN-VITRO, TOOTH MOVEMENTS, RESORPTION, ALENDRONATE, JAWS, OSTEOCLASTS, COMPLICATION, PAMIDRONATE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The present study was designed to evaluate the effects of risedronate, one of the most potent bisphosphonates, on alveolar bone resorption and angiogenesis in rats with experimental periodontitis to identify dose-response curves and treatment durations that can be therapeutic for periodontal therapy versus those associated with osteonecrosis of the jaws.