Significance of cagA status and vacA subtypes of Helicobacter pylori in determining gastric histopathology: Virulence markers of H-pylori and histopathology

KAKLIKKAYA N., Cubukcu K., AYDIN F., Bakir T., Erkul S., Tosun I., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.6, pp.1042-1047, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1746.2006.04199.x
  • Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1042-1047
  • Keywords: cagA status, Helicobacter pylori, histopathology, vacA subtypes, VACUOLATING CYTOTOXIN, SYDNEY SYSTEM, PEPTIC-ULCER, GENE, ASSOCIATION, EXPRESSION, GENOTYPES, STRAINS, CLASSIFICATION, DIVERSITY
  • Ondokuz Mayıs University Affiliated: No

Abstract

Background: It has been suggested that Helicobacter pylori strains containing the cytotoxin-associated gene A (cagA), and s1m1 genotype of vacuolating cytotoxin gene A (vacA) may have been associated with peptic ulcer disease. The aim of the present study was to analyze such an association of cagA presence and vacA subtypes of H. pylori with histopathological findings in patients with gastritis.