The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin

Hallak M., Balci H., Gunaydin C., Bilge S. S.

PHYSIOLOGY AND PHARMACOLOGY, cilt.23, sa.4, ss.302-308, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2019
  • Dergi Adı: PHYSIOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.302-308
  • Anahtar Kelimeler: Pregabalin, Somatic pain, Ketanserin, Atropine, TAIL-FLICK TEST, GABAPENTIN, SEROTONIN, MORPHINE, INVOLVEMENT, ACTIVATION, MECHANISMS, DRUGS, ACID, PAIN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Introduction: Pregabalin (PGB) is an analog of gamma-aminobutyric acid (GABA) with antinociceptive, antihyperalgesic and antiallodynic properties which frequently used in clinical pain management. Effect of PBG in neuropathic pain, incisional-inflammatory injury, post-operational pain, chronic pain and experimental pain models have already shown. It has been already known that muscarinic and serotonergic-2A receptors have a role in pain transmission.