Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer

Ergün S., GÜNEY S., TEMİZ E., Petrovic N., Güneş S.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.18, no.12, pp.1695-1701, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.2174/1871520618666180718100656
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1695-1701
  • Keywords: miRNA, ceRNA, NSCLC, miR-15a-5p, CNKSR3, prognostic biomarkers, EXPRESSION, MICRORNAS, METASTASIS, PREDICTION, PATHWAY, MIRSNPS, CASP3, SNPS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNA-based clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) would be the newest and the most effective approach to uncover novel interactions between mRNAs and miRNAs in NSCLC carcinogenesis. 'Mere are many factors influencing the efficiency of a miRNA to suppress or silence translation of the target mRNA. The most effective event is the presence of other RNAs showing ceRNA activity. These RNAs contain binding sites for specific miRNAs and enable miRNAs to bind these pseudo targets, instead of the original binding sites on the target mRNA. Therefore, the mRNA of the target gene is less affected by this miRNA, while the amount of miRNA remains the same in the media.