Clinical, pathological and immunohistochemical findings of bovine cutaneous papillomatosis
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.58, sa.3, ss.161-165, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1501/vetfak_0000002468
- Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.161-165
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Bovine cutaneous papillomatosis caused by a bovine papillomavirus, is a common skin disease in Turkey. The aim of the present study was to describe the clinical, histopathological and immunohistochemical aspects of naturally occurring bovine cutaneous papillomatosis. A total of 82 Holstein cattle (9.5%), aged between 5 and 24 months, were diagnosed as cutaneous papilloma by clinical examination. The percentage of papillonna and papillomatosis in male and female was found in 7.3% and 14.8%, respectively. The cauliflower-like growths of varying sizes (0.5-11 cm) were mostly located on the head (63.2%). Histopathology revealed various degrees of acanthosis and hyperkeratosis in all neoplasms. Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. Bovine papillomavirus (BPV-1) antigens were detected in the basal layer. In conclusion, it was decided that the BPV-1, PCNA and Ki-67 antibodies were very useful markers in the diagnosis of bovine cutaneous papilloma.