Adrenomedullin and total nitrite levels in children with familial Mediterranean fever

Balat A., Islek I., ÇEKMEN M. B., Yurekli M., TEKİN D., Muslu A., ...More

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, vol.42, no.5, pp.240-243, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1754.2006.00845.x
  • Journal Name: JOURNAL OF PAEDIATRICS AND CHILD HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.240-243
  • Keywords: adrenomedullin, familial Mediterranean fever, nitric oxide, TUMOR-NECROSIS-FACTOR, HYPOTENSIVE PEPTIDE, MESANGIAL CELLS, OXIDE SYNTHASE, MESSENGER-RNA, INTERLEUKIN-1, EXPRESSION, PATHWAY, ROLES
  • Ondokuz Mayıs University Affiliated: No

Abstract

Aim: Familial Mediterranean fever (FMF) is the most frequent periodic syndrome characterised by recurrent attacks of polyserositis. However, recent studies revealed that there might be an ongoing subclinical inflammation between the attacks. As nitric oxide (NO) and adrenomedullin (AM) are both synthesised in the endothelium, and mediates many functions within immune system, we considered them to be an interesting target of investigation in FMF.