JOURNAL OF PAEDIATRICS AND CHILD HEALTH, vol.42, no.5, pp.240-243, 2006 (SCI-Expanded)
Article / Article
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Science Citation Index Expanded (SCI-EXPANDED), Scopus
adrenomedullin, familial Mediterranean fever, nitric oxide, TUMOR-NECROSIS-FACTOR, HYPOTENSIVE PEPTIDE, MESANGIAL CELLS, OXIDE SYNTHASE, MESSENGER-RNA, INTERLEUKIN-1, EXPRESSION, PATHWAY, ROLES
Ondokuz Mayıs University Affiliated:
Aim: Familial Mediterranean fever (FMF) is the most frequent periodic syndrome characterised by recurrent attacks of polyserositis. However, recent studies revealed that there might be an ongoing subclinical inflammation between the attacks. As nitric oxide (NO) and adrenomedullin (AM) are both synthesised in the endothelium, and mediates many functions within immune system, we considered them to be an interesting target of investigation in FMF.