Effect of levetiracetam on penicillin induced epileptic activity in rats

Arik A. E., Bagirici F., Sefil F., Marangoz C.

ACTA NEUROBIOLOGIAE EXPERIMENTALIS, vol.74, no.3, pp.266-275, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 3
  • Publication Date: 2014
  • Journal Name: ACTA NEUROBIOLOGIAE EXPERIMENTALIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.266-275
  • Keywords: epilepsy, penicillin, rat, levetiracetam, ANTIEPILEPTIC DRUG LEVETIRACETAM, UCB L059, BRAIN TEMPERATURE, RECEPTOR-BINDING, ANTICONVULSANT, GABA, MECHANISMS, INHIBITION, SEIZURES, PROFILE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin- induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icy) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy.