Effect of levetiracetam on penicillin induced epileptic activity in rats

Arik A. E., Bagirici F., Sefil F., Marangoz C.

ACTA NEUROBIOLOGIAE EXPERIMENTALIS, cilt.74, sa.3, ss.266-275, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 3
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA NEUROBIOLOGIAE EXPERIMENTALIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.266-275
  • Anahtar Kelimeler: epilepsy, penicillin, rat, levetiracetam, ANTIEPILEPTIC DRUG LEVETIRACETAM, UCB L059, BRAIN TEMPERATURE, RECEPTOR-BINDING, ANTICONVULSANT, GABA, MECHANISMS, INHIBITION, SEIZURES, PROFILE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin- induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icy) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy.