Coumarin modified Silatrane: A potent probe for Hg(II) ion Detection, biological evaluation and Acetylcholinesterase inhibition

Singh G., Malik P., Heena H., Dege N., Devi S., Sharma D., ...Daha Fazla

INORGANIC CHEMISTRY COMMUNICATIONS, cilt.171, 2025 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 171
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.inoche.2024.113494
  • Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, DIALNET
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Mercury contamination poses significant threats to human health, aquatic ecosystems and various living organisms. Effective detection methods are essential for monitoring such contamination. In this investigation, coumarin-derivatized silatrane (CS) was synthesized and meticulously characterized using 1 H NMR, 13 C NMR and mass spectrometry. The CS compound exhibited outstanding performance in detecting Hg(II), showing excellent selectivity and sensitivity even in the presence of other metal ions with very low limit of detection value (LOD). Furthermore, the CS system exhibited promising performance in analyzing real water samples, yielding a recovery rate exceeding 95 %. Beyond its detection prowess, CS displayed notable biological properties, including significant radical scavenging activity. Molecular docking studies revealed its potential as an inhibitor of acetylcholinesterase (AChE) protein, suggesting a prospective role in combating Alzheimer disease's disease.