A 76 year-old female patient with a long-time history of nonspesific abdominal pain admitted to our hospital. Imaging studies showed 5 cm liver hydatid cyst between segments 2 and 3. She was recommended surgery and was informed about the details of single incision laparoscopic surgery (SILS). We performed single-incision laparoscopic pericystectomy. This is the first reported case of single-incision laparoscopic surgery for liver hydatid disease according to searching of English literature at the pubmed. SILS is a feasible surgical method for liver hydatid disease in selected patients with good outcome.