Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population

YİĞİT S., İNANIR A., Tekcan A., Inanir S., Tural Ş., Ates O.

GENE, vol.527, no.1, pp.62-64, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 527 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.gene.2013.04.020
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-64
  • Keywords: Fibromyalgia syndrome, Interleukin-4 gene (IL-4), Polymorphism, PAIN, INTERLEUKIN-4
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Purpose: Fibromyalgia (FM) syndrome is a form of non-articular rheumatism characterized by long term and widespread musculoskeletal pain, morning stiffness, sleep disturbance, paresthesia, and pressure hyperalgesia at characteristic sites, called soft tissue tender points. The etiology of FM is still obscure. Genetic factors may predispose individuals to FM. Cytokines may play a role in the pathophysiology of FM. The aim of this study was to investigate the interleukin-4 (IL-4) 70 bp VNTR variations in Turkish patients with FM and evaluate if there was an association with clinical features, especially between these polymorphisms.